A 146-dB-Ohm Gain 14-pARMS Noise Patch-Clamp Amplifier for Whole-Cell Ion Current Detection

The membrane clamp technique is an important tool to reflect the electrophysiological characteristics of cells by recording ionic currents cellular channels. Embedded systems work in designed for specific user groups and are used implement functions. amplifier built with embedded technology has advantages miniaturization, specialization, low power consumption, high integration, resource utilization, a long life cycle, which can avoid inconvenience developers experimenters due update general-purpose computer software hardware. In this paper, patch-clamp (PCA) based on transimpedance (TIA) proposed, includes glass microelectrode series resistance/capacitance compensation circuit feedback resistor parasitic capacitance compensation. prototype using 180 nm CMOS occupies area 720 μ m × 630 . achieves gain 145.6 dB-Ohm, -3 dB bandwidth greater than 15 kHz, input reference noise current 13.98 pARMS. Experimental results show that proposed PCA capable compensating up 30 pF electrode 10 MΩ 86% resistance, respectively. addition, when enabled, overshoot phenomenon disappears, overcoming shortcomings conventional diaphragm maintaining original key performance.